Archives Family Medicine September 1994, 3:809-820 Atherosclerotic plaques may be caused by oxidation of LDL (the so called “bad cholesterol”). Antioxidant nutrients may prevent or delay oxidation and plaque formation. There is some evidence that vitamin E may decrease the oxidation of LDL. Vitamin C may play a role because it helps to regenerate oxidized vitamin E. Vitamin C can also help regenerate glutathione (another important antioxidant). A significant lowering of the incidence of cardiovascular disease and death was seen in people who had higher intakes of vitamin C in a cohort study involving 11,000 people.