Vitamin A and Cancer

Cancer Letters, 1991; 59:25-29 “Anti-Tumor Effects of Vitamin A Against Shope Carcinoma Cells” Retinol (vitamin A) caused growth retardation as well as changes in morphology in Shope carcinoma (cultured). The authors came to the conclusion that vitamin A may be effective against differentiated squamous cell carcinomas. However, it may not be effective against undifferentiated tumors.

Nutrition and Cancer, “Exposure to Benzopyrene Depletes Tissue Vitamin A: B-Carotene Prevents Depletion”,1991; 208-210. Rats fed benzopyrene had tissue retinol reduce by 30% in the small intestine and liver. Supplementing the rats with beta carotene prevented the retinol reduction. It is possible that taking beta carotene may have a positive impact on environmental carcinogens.

American Journal of Epidemiology, 1991; 133: 766-75. “Plasma Antioxidant Vitamins and Subsequent Cancer Mortality in 12-Year Follow-up of the Prospective Basal Study” Over a two-year period, antioxidant vitamins (vitamins A, C and E) were measured in 2974 men. During the course of the study, 204 men died of cancer. In general, mortality was associated with low levels of vitamin C and carotene.

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