Twenty children took part in a double-blind, placebo-controlled study published in theAmerican Journal of Psychiatry (2006; 163(6): 1098-100). The subjects were divided into two groups; one group was given omega-3 supplementation (a combination of EPA and DHA) and the second group was given a placebo. The children were evaluated using the Children’s Depression Scale, Children’s Depression Inventory, and Clinical Global Impression at the beginning of the study, and after two, four, 12 and 16 weeks. At the end of the study, seven of the 10 children taking the supplement had at least a 50% improvement in their depression scores. No improvement was seen in the placebo group.